Sorafenib Tosylate , ≥99% , 475207-59-1

CAS NO.：475207-59-1

Empirical Formula: C28H24ClF3N4O6S

Molecular Weight: 637.03

MDL number: MFCD08235032

EINECS: 641-758-8

PRODUCT Properties

• Melting point: 229-232°C
• storage temp.: 2-8°C(protect from light)
• solubility: Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 3 mg/ml).
• form: solid
• color: Off-white
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
• InChIKey: IVDHYUQIDRJSTI-UHFFFAOYSA-N
• SMILES: S(C1C=CC(C)=CC=1)(O)(=O)=O.O(C1C=CC(NC(=O)NC2C=CC(Cl)=C(C(F)(F)F)C=2)=CC=1)C1=CC=NC(C(=O)NC)=C1
• CAS DataBase Reference: 475207-59-1(CAS DataBase Reference)

Description and Uses

Sorafenib (475207-59-1) was initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-β (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM).1?Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms.2?Inhibits activation of MAPK pathway and ERK phosphorylation.3?Induces caspase-independent apoptosis in melanoma cells.4?Sorafenib is a clinically useful anticancer agent.

Sorafenib Tosylate (Bay 43-9006, Nexavar) is a small molecular inhibitor of VEGFR, PDGFR, c-Raf and B-Raf with IC50s of 18 nM, 10 nM, 3 nM and 15 nM, respectively.

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Danger
• Hazard statements: H360FD-H362-H372-H410
• Precautionary statements: P201-P202-P260-P263-P273-P308+P313
• Risk Statements: 36/37/38
• Safety Statements: 28-26
• HS Code: 29159000