Salmon Calcitonin Acetate , ≥97%(HPLC) , 47931-85-1

Synonym(s):
Calcitonin, Salmon;Thyrocalcitonin

CAS NO.：47931-85-1

Empirical Formula: C145H240N44O48S2

Molecular Weight: 3431.85

MDL number: MFCD00133859

EINECS: 256-342-8

PRODUCT Properties

• Melting point: >222oC (dec.)
• Density: 1.54±0.1 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: 0.05 M acetic acid: 1 mg/mL, clear, colorless
• form: powder
• color: White to Off-White
• Water Solubility: Soluble in water at 1mg/ml
• Merck: 13,1642
• Sequence: H-[Cys-Ser-Asn-Leu-Ser-Thr-Cys]-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2，(Disulfide bridge: Cys1-Cys7)
• InChIKey: IYTKRMFJECGBRF-LXQLIYPUSA-N
• CAS DataBase Reference: 47931-85-1(CAS DataBase Reference)

Description and Uses

Calcitonin is a single-chain polypeptide consisting of 32 amino acid residues. Calcitonins as obtained from different species are identical at seven of the first nine residues, contain Gly at position 28, and all terminate with Pro-NH2. The C-terminal proline amide (ProNH2) is very important for the biological function of CT, as is the disulfide bridge between Cys residues at positions 1 and 7. In contrast, the residues from 10 through 27 can be varied and seem to influence CT's potency as well as its duration of action. Salmon CT differs from human CT at 16 amino acid residues.

Calcitonin salmon can be used for calcitonin receptor/cAMP assay for assessing the presence of calcitonin receptors expressed by TRAP+ cells.The product can also be used as a test compound for studying as well as comparing the impact of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric mucosal barrier in rats exposed to cold + restraint stress (CRS).

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P310+P330
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: EV8000000
• F: 3-10
• HS Code: 2937190000