Home Categories API Spectinomycin pentahydrate dihydrochloride
A7342612

Spectinomycin pentahydrate dihydrochloride , potency:≥603μg/mg , 22189-32-8

Synonym(s):
Spectinomycin;Spectinomycin dihydrochloride pentahydrate

CAS NO.:22189-32-8

Empirical Formula: C14H24N2O7.2HCl.5H2O

Molecular Weight: 495.35

MDL number: MFCD00070403

EINECS: 606-950-8

Pack Size Price Stock Quantity
1G RMB28.80 In Stock
5G RMB99.20 In Stock
25G RMB361.60 In Stock
100g RMB1080.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 205-207° (dec)
alpha  D +14.8° (c = 0.42 in water)
storage temp.  2-8°C
solubility  H2O: 50 mg/mL, clear, faintly yellow
form  powder
color  white to off-white
Water Solubility  Soluble in water.Soluble in water, methanol, dimethyl sulfoxide, ethanol and dimethyl formamide.
Merck  14,8739
BRN  5684150
InChIKey DCHJOVNPPSBWHK-UXXUFHFZSA-N
CAS DataBase Reference 22189-32-8

Description and Uses

Spectinomycin was found in the culture broth of Streptomyces spectabilis by Upjohn Co. in 1961. This antibiotic was intended for use in treating various infections, as are the other aminoglycoside antibiotics, but its activity is insufficient for clinical efficacy except against gonorrhea. Spectinomycin does not develop crossresistance with any other antibiotic and shows low toxicity; it is used by deep intramuscular injection for “single-session,” bolusinjection therapy of gonorrhea.

Spectinomycin is an aminocyclitol antibiotic produced by S. spectabilis that is active against Gram-negative and Gram-positive bacteria. Spectinomycin inhibits protein synthesis by binding to the 30S ribosomal subunit and interfering with peptidyl tRNA translocation. Mutations in the gene for ribosomal protein S5 prevents binding of spectinomycin and contributes to bacterial resistance.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Safety Statements  24/25
WGK Germany  2
RTECS  WG7400000
10
HS Code  29419090
Toxicity mouse,LD50,intramuscular,> 5gm/kg (5000mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Japanese Journal of Antibiotics. Vol. 29, Pg. 43, 1976.

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