Spectinomycin pentahydrate dihydrochloride , potency:≥603μg/mg , 22189-32-8

Synonym(s):
Spectinomycin;Spectinomycin dihydrochloride pentahydrate

CAS NO.：22189-32-8

Empirical Formula: C14H24N2O7.2HCl.5H2O

Molecular Weight: 495.35

MDL number: MFCD00070403

EINECS: 606-950-8

PRODUCT Properties

• Melting point: 205-207° (dec)
• alpha: D +14.8° (c = 0.42 in water)
• storage temp.: 2-8°C
• solubility: H₂O: 50 mg/mL, clear, faintly yellow
• form: powder
• color: white to off-white
• Water Solubility: Soluble in water.Soluble in water, methanol, dimethyl sulfoxide, ethanol and dimethyl formamide.
• Merck: 14,8739
• BRN: 5684150
• InChIKey: DCHJOVNPPSBWHK-UXXUFHFZSA-N

Description and Uses

Spectinomycin was found in the culture broth of Streptomyces spectabilis by Upjohn Co. in 1961. This antibiotic was intended for use in treating various infections, as are the other aminoglycoside antibiotics, but its activity is insufficient for clinical efficacy except against gonorrhea. Spectinomycin does not develop crossresistance with any other antibiotic and shows low toxicity; it is used by deep intramuscular injection for “single-session,” bolusinjection therapy of gonorrhea.

Spectinomycin is an aminocyclitol antibiotic produced by S. spectabilis that is active against Gram-negative and Gram-positive bacteria. Spectinomycin inhibits protein synthesis by binding to the 30S ribosomal subunit and interfering with peptidyl tRNA translocation. Mutations in the gene for ribosomal protein S5 prevents binding of spectinomycin and contributes to bacterial resistance.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Safety Statements: 24/25
• WGK Germany: 2
• RTECS: WG7400000
• F: 10
• HS Code: 29419090
• Toxicity: mouse,LD50,intramuscular,> 5gm/kg (5000mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Japanese Journal of Antibiotics. Vol. 29, Pg. 43, 1976.