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A7324912

Spermine , forcellculture,≥98.0%(GC) , 71-44-3

Synonym(s):
N,N′-Bis(3-aminopropyl)-1,4-diaminobutane;Gerontine;Musculamine;Neuridine

CAS NO.:71-44-3

Empirical Formula: C10H26N4

Molecular Weight: 202.34

MDL number: MFCD00012914

EINECS: 200-754-2

Pack Size Price Stock Quantity
1G RMB396.80 In Stock
5G RMB1594.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 28-30 (lit.)
Boiling point: 150 °C/5 mmHg (lit.)
Density  0.937
refractive index  1.4850 (estimate)
Flash point: >230 °F
storage temp.  2-8°C
solubility  H2O: 1 M at 20 °C, clear, colorless
form  powder
pka 10.88±0.19(Predicted)
color  Colorless to off-white
Water Solubility  Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether.
Sensitive  Air Sensitive & Hygroscopic
Merck  14,8743
BRN  1751791
Stability: Hygroscopic
InChIKey PFNFFQXMRSDOHW-UHFFFAOYSA-N
LogP -0.543 (est)
CAS DataBase Reference 71-44-3(CAS DataBase Reference)
NIST Chemistry Reference Spermine(71-44-3)
EPA Substance Registry System 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3)

Description and Uses

Spermine is an endogenous polyamine synthesized from the reaction of spermidine with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.

immune modulator

Safety

Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H318-H314
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P305+P351+P338-P310
Hazard Codes  Xi,C
Risk Statements  36/38-34
Safety Statements  26-36-45-36/37/39-27
RIDADR  UN 3259 8/PG 2
WGK Germany  3
RTECS  EJ7230000
3-10
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29212900

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