PRODUCT Properties
| Melting point: | 126-128 °C |
| Boiling point: | 914℃ |
| alpha | D20 -80° (methanol) |
| refractive index | 81 ° (C=2, 10% AcOH) |
| Flash point: | >110°(230°F) |
| storage temp. | 2-8°C |
| solubility | ethanol: 50 mg/mL, clear to slightly hazy, light-yellow |
| form | powder |
| color | white to light yellow |
| optical activity | [α]/D -85 to -80° in water (Specific rotation (dry basis)) |
| Water Solubility | Soluble in methanol. Slightly soluble in water |
| Merck | 14,8752 |
| CAS DataBase Reference | 8025-81-8 |
Description and Uses
Spiramycin was found in the culture broth of Streptomyces ambofaciens by Rhone Poulenc in 1954 and its acetate was synthesized by Kyowa Hakko Kogyo Co. in 1965. This antibiotic consists of three closely related macrolide components, I, II, and III, whose ratio is 2 : 1 : 1. Spiramycin shows almost the same antimicrobial spectrum and activity as the other macrolides, but its acetate, acetylspiramycin, has much better pharmacokinetic properties and activity in vivo.
vitamin A
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H303 |
| Precautionary statements | P270-P301+P312-P403-P501c |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25 |
| WGK Germany | 1 |
| RTECS | WG9400000 |
| F | 10 |
| HS Code | 29419090 |
| Hazardous Substances Data | 8025-81-8(Hazardous Substances Data) |
| Toxicity | LD50 in rats (mg/kg): 9400 orally; 1000 s.c.; 170 i.v. (Sous) |
