Tauroursodeoxycholic Acid Dihydrate , 98% , 14605-22-2

Synonym(s):
Sodium Tauroursodeoxycholate;Tauroursodeoxycholic Acid, Sodium Salt - CAS 14605-22-2 - Calbiochem

CAS NO.：14605-22-2

Empirical Formula: C26H45NO6S

Molecular Weight: 499.7

MDL number: MFCD00069496

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: 173-175°C
• Density: 1.216±0.06 g/cm3(Predicted)
• refractive index: 46 ° (C=1, EtOH)
• storage temp.: 15-25℃
• solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
• form: solid
• pka: 1.42±0.50(Predicted)
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
• InChIKey: BHTRKEVKTKCXOH-LBSADWJPSA-N
• SMILES: [C@@]12([H])CC[C@H]([C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@@H](O)C[C@@]3([H])C[C@H](O)[C@@]21[H] |&1:0,4,5,18,22,24,28,31,34,36,r|

Description and Uses

Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid synthesized in hepatocytes by the conjugation of ursodeoxycholic acid (UDCA) with the amino acid taurine. UDCA, which is made by gut bacteria, is FDAapproved in the United States for the treatment of certain cholestatic liver diseases. Humans make TUDCA to some extent, but it is found in copious amounts in the bile of bears. TUDCA is a classic inhibitor of endoplasmic reticulum (ER) stress. Reduces ER stress and adipose tissue inflammation in a mouse model of high fat diet-induced obesity. Blocks ER stress-induced NLRP3 inflammasome activation and hepatocyte death. Attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mouse model.

Tauroursodeoxycholic acid (TUDCA) is a water-soluble bile salt naturally occurring in the body. When bile salts reach the intestines, they can be metabolized by bacteria into ursodeoxycholic acid (UDCA). TUDCA is formed when taurine binds to UDCA. TUDCA is used to treat cholestasis, a condition in which bile fails to flow from the liver to the duodenum. TUDCA, UDCA, and other soluble bile salts can counteract the toxicity of regular bile acids when the latter are backed up in the liver. TUDCA is also used to treat cholesterol gallstones, dissolving them to a size in which they may be passed.

Safety

• Safety Statements: 22-24/25
• WGK Germany: 2
• RTECS: KI7372500
• HS Code: 29242990
• Toxicity: mouse,LD50,intravenous,350mg/kg (350mg/kg),Japanese Kokai Tokyo Koho Patents. Vol. #92-235918,