(R)-(-)-2-Amino-5-phosphonopentanoic acid , 98% , 79055-68-8

Synonym(s):
D(−)-AP-5;D(−)-APV;D-2-Amino-5-phosphonovaleric acid;D-(–)-2-Amino-5-phosphonopentanoic Acid - CAS 79055-68-8 - Calbiochem;D-AP5, NMDA Antagonist II, APV, D-APV, 2-APV, D-2-amino-5-phosphonovalerate

CAS NO.：79055-68-8

Empirical Formula: C5H12NO5P

Molecular Weight: 197.13

MDL number: MFCD00078839

PRODUCT Properties

• Melting point: approximate 233℃
• Boiling point: 482.1±55.0 °C(Predicted)
• Density: 1.529±0.06 g/cm3(Predicted)
• RTECS: RD2513000
• storage temp.: Store at RT
• solubility: Soluble to 100 mM in sterile
• form: White solid
• pka: 2.46±0.10(Predicted)
• color: White
• Water Solubility: Soluble in water (100mM)
• Sensitive: Light Sensitive

Description and Uses

D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (K_d = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.

A competitive NMDA antagonist

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3