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A7133412

Repaglinide , ≥99% , 135062-02-1

Synonym(s):
(S)-(+)-2-Ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid;Novonorm;Prandin;Repaglinide

CAS NO.:135062-02-1

Empirical Formula: C27H36N2O4

Molecular Weight: 452.59

MDL number: MFCD00906179

EINECS: 629-921-1

Pack Size Price Stock Quantity
50MG RMB47.20 In Stock
250MG RMB113.60 In Stock
1g RMB214.40 In Stock
200mg RMB608.00 In Stock
5g RMB828.80 In Stock
25g RMB3116.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 129-130.2 °C
alpha  D20 +6.97° (c = 0.975 in methanol); D20 +7.45° (c = 1.06 in methanol)
Boiling point: 672.9±55.0 °C(Predicted)
Density  1.137±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: 34 mg/mL
form  solid
pka 4.19±0.10(Predicted)
color  white
Water Solubility  89.99mg/L(25 ºC)
Merck  14,8136
InChIKey FAEKWTJYAYMJKF-QHCPKHFHSA-N
SMILES C(O)(=O)C1=CC=C(CC(N[C@H](C2=CC=CC=C2N2CCCCC2)CC(C)C)=O)C=C1OCC
CAS DataBase Reference 135062-02-1(CAS DataBase Reference)

Description and Uses

Repaglinide was marketed in the US as an orally active hypoglycemic agent in patients with a type Ⅱ diabetes mellitus, to lower blood glucose in synergistic combination with metformin, when hyperglycemia cannot be controlled by diet, exercise or metformin alone. Chiral (S)-repaglinide can be synthesized in several ways, each involving a stereoselective reduction of an imine or enamine group. Repaglinide is a nonsulfonylurea belonging to the meglitinide family, with an insulin-releasing effect mediated by pancreatic betacells, by closing the ATP-sensitive K+ channels that, in turn, increases the cytosolic concentration of Ca++. In several animal models, repaglinide was more efficient than glibenclamide as a dose-dependant promoter of insulin release, but its mechanism of action is probably slightly different. Repaglinide has a rapid onset of action, a short duration of action and a reduced risk of hypoglycemia compared to glyburide.

A KIR6 (KATP) channel blocker

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H361-H362
Precautionary statements  P501-P263-P260-P270-P202-P201-P264-P280-P308+P313-P301+P312+P330-P405
WGK Germany  2
RTECS  000000033825
HS Code  2933399090
Toxicity LD50 orally in rats: >1 g/kg (Grell)

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