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A6212412

Nateglinide , ≥99% , 105816-04-4

Synonym(s):
Fastic;N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanine;Starlix;Starsis

CAS NO.:105816-04-4

Empirical Formula: C19H27NO3

Molecular Weight: 317.42

MDL number: MFCD00875706

EINECS: 641-756-7

Pack Size Price Stock Quantity
250MG RMB28.00 In Stock
1G RMB44.80 In Stock
5G RMB120.00 In Stock
25G RMB412.80 In Stock
100g RMB1417.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 137-141°C
alpha  D20 -9.4° (c = 1 in methanol)
Boiling point: 527.6±39.0 °C(Predicted)
Density  1.104±0.06 g/cm3(Predicted)
storage temp.  room temp
solubility  DMSO: >5mg/mL
pka 3.61±0.10(Predicted)
form  solid
color  white to off-white
Merck  14,6428
CAS DataBase Reference 105816-04-4(CAS DataBase Reference)

Description and Uses

Nateglinide is a N-acylated D-phenylalanine marketed in Japan as novel orally active insulinotropic agent for the treatment of type-2 diabetes mellitus. It belongs to the class of nonsulfonylureas and shows some structural similarity to repaglinide, the only other representative in this family. In single pancreatic beta-cells isolated from rats, Nateglinide was found to specifically block the ATP-sensitive K+ channel resulting in an increase in intracellular calcium concentration. This primary action would underlie the mechanism by which Nateglinide markedly stimulates or potentiates, depending on glucose concentrations, insulin secretion from pancreatic beta-cells. Clinical studies demonstrated a good safety profile with a low potential for hypoglycemia. The pharmacokinetic profile was consistent with the changes of the blood glucose and plasma insulin level. Interestingly, Nateglinide exerts a rapid onset and short duration of action due to a rapid absorption and clearance. Unlike other similar agents, Nateglinide suppresses postprandial glucose elevations.

An amino-acid derivative that stimulates insulin secretion. Used as an antidiabetic.

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H361
Precautionary statements  P201-P202-P281-P308+P313-P405-P501
Hazard Codes  Xn
Risk Statements  22
Safety Statements  24/25-36
WGK Germany  3
RTECS  SQ7318950
HS Code  29242990
Toxicity LD50 orally in rats: >2.0 g/kg (Hasegawa)

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