Racecadotril , ≥98% , 81110-73-8

Synonym(s):
(±)-Acetorphan;(RS)-Benzyl N-[3-(acetylthio)-2-benzylpropanoyl]glycinate;Acetorphan;Cadotril;Redotil

CAS NO.：81110-73-8

Empirical Formula: C21H23NO4S

Molecular Weight: 385.48

MDL number: MFCD00865520

EINECS: 688-010-7

PRODUCT Properties

• Melting point: 89°C
• Boiling point: 574.5±50.0 °C(Predicted)
• Density: 1.206
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: DMSO: ≥44mg/mL
• pka: 13.63±0.46(Predicted)
• form: powder
• color: white to tan
• Merck: 14,8090
• InChI: InChI=1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)
• InChIKey: ODUOJXZPIYUATO-UHFFFAOYSA-N
• SMILES: C(OCC1=CC=CC=C1)(=O)CNC(=O)C(CSC(C)=O)CC1=CC=CC=C1

Description and Uses

Racecadotril, also known as acetorphan, is a kind of antidiarrheal drug acting as a peripherally acting enkephalinase inhibitor. It belongs to the group of gastrointestinal drugs and is also a lipophilic derivative of Thiorphan. Racecadotril is a dipeptide in which there is a single amide bond. It has an antisecretory effect, reducing the secretion of water and electrolytes into the intestine. Racecadotril is a pro-drug that is metabolized in vivo into the active compound, thiorphan. Thiorphan exerts its inhibitory effect on enkephalinase, reducing the amount of secreted water produced by the intestines. In this case, the body loses less fluid, and the symptoms of diarrhea can be alleviated.

Racecadotril is an enkephalinase inhibitor that prevents the degradation of endogenous opioids. It demonstrates antidiarrheal activity by reducing hypersecretion of water and electrolytes into the intestinal lumen. It is an effective and safe treatment for acute diarrhea in adults and children.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H302-H400
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn,N
• Risk Statements: 22-50/53
• Safety Statements: 60-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: MB7606872
• HS Code: 29309090