Home Categories Biochemical Engineering Rilpivirine
A7128312

Rilpivirine , ≥98% , 500287-72-9

CAS NO.:500287-72-9

Empirical Formula: C22H18N6

Molecular Weight: 366.42

MDL number: MFCD11046372

Pack Size Price Stock Quantity
10MG RMB55.20 In Stock
50MG RMB183.20 In Stock
100mg RMB346.40 In Stock
250mg RMB663.20 In Stock
1g RMB1656.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 245℃
Boiling point: 634.1±65.0 °C(Predicted)
Density  1.27
storage temp.  Refrigerator
solubility  Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Water (Very Slightly)
pka 4.56±0.10(Predicted)
form  Solid
color  Yellow

Description and Uses

In May 2011, the U.S. FDA approved rilpivirine in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) 1 infection in treatment-naive adult patients. Rilpivirine is a member of the nonnucleoside reverse transcriptase inhibitor (NNRTI) class of anti-HIV agents. It is highly potent against a range of wild-type HIV strains (EC50=0.07–1.0 nM),~10–20 timesmore potent than the NNRTI efavirenz (Sustiva), and active against HIV strains resistant to other NNRTIs. The discovery of rilpivirine was guided by molecular modeling and X-ray crystallography of HIV-1 RT complexed with inhibitors. The synthesis of rilpivirine is accomplished by an efficient 6-step route in which the key step is coupling of 4-((4-chloropyrimidin-2-yl)amino)benzonitrile with (E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile.

A novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.

Safety

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H319-H400-H302-H410
Precautionary statements  P273-P391-P501-P264-P270-P301+P312-P330-P501-P273-P391-P501-P264-P280-P305+P351+P338-P337+P313P
Hazardous Substances Data 500287-72-9(Hazardous Substances Data)

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