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A7103658

Chlorotetracyclinehydrochloride , 2mMinDMSO , 64-72-2

Synonym(s):
7-Chlorotetracycline hydrochloride;Chlortetracycline hydrochloride

CAS NO.:64-72-2

Empirical Formula: C22H24Cl2N2O8

Molecular Weight: 515.34

MDL number: MFCD26142699

EINECS: 200-591-7

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 210-215 °C (dec.)(lit.)
alpha  D23 -240°
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  1 M NaOH: soluble50mg/mL
form  Powder
color  faint yellow to yellow
pka 3.3(at 25℃)
Water Solubility  Soluble in water
Sensitive  Light Sensitive
Merck  13,2211
BRN  3858364

Description and Uses

Chlortetracycline was found in the culture broth of Streptomyces aureofaciens by Duggar et al. of Lederle Laboratories in 1948 and named aureomycin. It shows a wider range of antibiotic activity than the earlier antibiotics, penicillins, and streptomycins and as great as that of chloramphenicol. Its activity covers grampositive and gram-negative bacteria as well as Rickettsia and Chlamydiae. Chlortetracycline has been replaced by other tetracyclines in clinical use and is used now used as a feed additive to promote the growth of livestock.

Chlortetracycline hydrochloride is a salt prepared from chlortetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, chlortetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H315-H317-H319-H335-H361fd
Precautionary statements  P202-P261-P280-P302+P352-P305+P351+P338-P308+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  QI7800000
HazardClass  3
HS Code  29413020
Toxicity LD50 orally in rats: 10300 mg/kg (Goldenthal)

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