A7074858
CB-103 , 10mMinDMSO , 218457-67-1
Pack Size | Price | Stock | Quantity |
1ml | RMB159.20 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | 89-90 |
storage temp. | 2-8°C |
solubility | Soluble in DMSO (>30 mg/ml) |
form | solid |
color | Off-white to pale orange |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
CAS DataBase Reference | 218457-67-1(CAS DataBase Reference) |
Description and Uses
CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines.? CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P271-P261-P280 |
Hazard Codes | Xi |
Hazard Note | Irritant |
HS Code | 2933399990 |