PRODUCT Properties
| Melting point: | 125-128 °C (lit.) |
| Boiling point: | 228°C |
| Density | 1.341 |
| vapor pressure | 0.000056 hPa (20 °C) |
| refractive index | 1.5323 (estimate) |
| Flash point: | 180°C |
| storage temp. | Store below +30°C. |
| solubility | ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to light yellow |
| form | Crystalline Powder |
| pka | 13.0(at 25℃) |
| color | White to almost white |
| PH Range | 6.9 |
| PH | 6.9 (H2O)(saturated solution) |
| Water Solubility | 1.35 g/100 mL (20 ºC) |
| Merck | 14,1060 |
| BRN | 385876 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| LogP | 0.640 |
| CAS DataBase Reference | 55-21-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzamide(55-21-0) |
| EPA Substance Registry System | Benzamide (55-21-0) |
Description and Uses
Benzamide appears as off-white crystals or powder. It is combustible and incompatible with strong oxidising agents and strong bases. On combustion and thermal decomposition, it emits nitrogen oxides, carbon monoxide, and carbon dioxide.
Benzamide is a carbonic acid amide of benzoic acid. Benzamide exhibits an angle of about 15º with the plane of the amide group; this shows that benzamide molecule is not flat. The rotation of the amide group relative to the aromatic ring may result from the repulsion interaction between the hydrogen atoms of the amide group and those of the aromatic ring.
Benzamide is utilized to study the mechanism of photocatalytic decomposition of aqueous solution of acetic acid, acetamide and acetonitrile in the presence of semiconductors. It is used as a nictoinamide-mimic PARP inhibitor and neuroprotectant. Further, it is used to develop a robust screening method to study biotransformations using (+)-gamma-lactamase enzyme. It is also employed in the determination of glycine. In addition to this, it is used as an intermediate in organic synthesis as well as in the production of pharmaceuticals and dyes.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302-H341 |
| Precautionary statements | P201-P301+P312+P330-P308+P313 |
| Hazard Codes | Xn |
| Risk Statements | 22-68 |
| Safety Statements | 22-24/25-36/37 |
| WGK Germany | 1 |
| RTECS | CU8700000 |
| Autoignition Temperature | >500 °C |
| TSCA | Yes |
| HS Code | 29242995 |
| Hazardous Substances Data | 55-21-0(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 1125 mg/kg |
