PRODUCT Properties
| Melting point: | 88-90 °C (lit.) |
| Boiling point: | 133.7°C (rough estimate) |
| Density | 1.2269 (rough estimate) |
| refractive index | 1.4264 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Methanol (Sparingly), Water (Sparingly) |
| form | Crystalline Solid |
| pka | 8.70(at 25℃) |
| color | White to pale yellow |
| Water Solubility | Soluble in water. |
| Sensitive | Hygroscopic |
| Merck | 14,63 |
| BRN | 1739019 |
| Stability: | Moisture and Temperature Sensitive |
| InChIKey | RRUDCFGSUDOHDG-UHFFFAOYSA-N |
| CAS DataBase Reference | 546-88-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetamide,N-hydroxy(546-88-3) |
| EPA Substance Registry System | Acetohydroxamic acid (546-88-3) |
Description and Uses
Acetohydroxamic acid is a potent, non-competitive and irreversible inhibitor of bacterial urease (Ki≈lO-7M). This enzyme, which is widely distributed in plants and bacteria, but not in mammalian cells, catalyzes the decomposition of urea to ammonia. Elevated urinary ammonia levels can reduce the antibacterial effectiveness of a number of agents. Thus, acetohydroxamic acid is useful as adjunctive therapy to decrease urinary ammonia and alkalinity in patients with chronic urea-splitting urinary infection. Such infections are a leading cause of recurring complications and death in paraplegics.
A urease inhibitor. Used in the synthesis
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H360 |
| Precautionary statements | P201-P280-P308+P313 |
| Hazard Codes | T |
| Risk Statements | 61-40 |
| Safety Statements | 53-45-36/37/39-22 |
| RIDADR | 3263 |
| WGK Germany | 3 |
| RTECS | AK8157000 |
| Hazard Note | Toxic |
| PackingGroup | II |
| HS Code | 29225090 |
| Hazardous Substances Data | 546-88-3(Hazardous Substances Data) |
| Toxicity | mmo-sat 160 mmol/plate JOPHDQ 3,557,80 |
