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A7051058

Acetohydroxamicacid , 10mMinDMSO , 546-88-3

Synonym(s):
AHA

CAS NO.:546-88-3

Empirical Formula: C2H5NO2

Molecular Weight: 75.07

MDL number: MFCD00009994

EINECS: 208-913-8

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 88-90 °C (lit.)
Boiling point: 133.7°C (rough estimate)
Density  1.2269 (rough estimate)
refractive index  1.4264 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Methanol (Sparingly), Water (Sparingly)
form  Crystalline Solid
pka 8.70(at 25℃)
color  White to pale yellow
Water Solubility  Soluble in water.
Sensitive  Hygroscopic
Merck  14,63
BRN  1739019
Stability: Moisture and Temperature Sensitive
InChIKey RRUDCFGSUDOHDG-UHFFFAOYSA-N

Description and Uses

Acetohydroxamic acid is a potent, non-competitive and irreversible inhibitor of bacterial urease (Ki≈lO-7M). This enzyme, which is widely distributed in plants and bacteria, but not in mammalian cells, catalyzes the decomposition of urea to ammonia. Elevated urinary ammonia levels can reduce the antibacterial effectiveness of a number of agents. Thus, acetohydroxamic acid is useful as adjunctive therapy to decrease urinary ammonia and alkalinity in patients with chronic urea-splitting urinary infection. Such infections are a leading cause of recurring complications and death in paraplegics.

A urease inhibitor. Used in the synthesis

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360
Precautionary statements  P201-P280-P308+P313
Hazard Codes  T
Risk Statements  61-40
Safety Statements  53-45-36/37/39-22
RIDADR  3263
WGK Germany  3
RTECS  AK8157000
Hazard Note  Toxic
PackingGroup  II
HS Code  29225090
Toxicity mmo-sat 160 mmol/plate JOPHDQ 3,557,80

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