CefotiamDihydrochloride , 10mMinDMSO , 66309-69-1
Synonym(s):
;(6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride hydrate;Cefotiam dihydrochloride
CAS NO.：66309-69-1
Empirical Formula: C18H23N9O4S3.HCl
Molecular Weight: 562.08
MDL number: MFCD01682052
EINECS: 266-312-6
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >93°C (dec.) |
| Boiling point: | 94℃ |
| RTECS | XI0367000 |
| Flash point: | >110°(230°F) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: ≥22M |
| form | powder |
| color | white to tan |
| Water Solubility | Soluble in water |
| Stability: | Hygroscopic |
| InChIKey | BWRRTAXZCKVRON-DGPOFWGLSA-N |
| CAS DataBase Reference | 66309-69-1(CAS DataBase Reference) |
Description and Uses
Cefotiam was synthesized by Takeda Chemicals Industries in 1977 as the first cephem derivative to introduce the aminothiazol group in the 7 side chain and the alkylated tetrazole group at the 3 side chain . This drug shows greater antibacterial activity against gram-negative bacteria than the earlier cephalosporins, including Enterobacter, Citrobacter, and indole-positive Proteus, and it retains the same activity as they have against gram-positive organisms. Its excellent activity against Klebsiella and Escherichia coli is based on its ability to penetrate the cell. This is 3- to 70-fold greater than that of cephalothin or cefazolin.
Cefotiam hydrochloride (SCE-963 hydrochloride) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.
