Aurantio-obtusin , 10mMinDMSO , 67979-25-3
Synonym(s):
1,3,7-Trihydroxy-2,8-dimethoxy-6-methyl-9,10-anthracenedione
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 265-266 °C |
| Boiling point: | 594.6±50.0 °C(Predicted) |
| Density | 1.510±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in chloroform, DMSO and methan |
| form | powder |
| pka | 6.32±0.20(Predicted) |
| color | Orange |
Description and Uses
Aurantioobtusin is an anthraquinone originally isolated from Cassia seeds with diverse biological activities. It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 13.6 μM). Aurantioobtusin (10 and 100 μM) activates the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner. It inhibits rat platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), ADP, and collagen. Aurantioobtusin induces vasorelaxation in isolated precontracted rat mesenteric artery rings, an effect that is inhibited by the PI3K inhibitor LY290042 or inhibition of endothelial nitric oxide synthase (eNOS). It is larvicidal against A. gambiae mosquitoes (LD50 = 10 ppm).
A compound found in herbal remedies, believed to have an effect on blood platelet aggregation and lower blood lipid count
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Safety Statements | 24/25 |
| HS Code | 29389090 |
