A7021658
Betulinicacid , 10mMinDMSO , 472-15-1
Synonym(s):
3β-Hydroxy-20(29)-lupaene-28-oic acid;Lupatic acid;Mairin
CAS NO.：472-15-1
Empirical Formula: C30H48O3
Molecular Weight: 456.71
MDL number: MFCD00009619
EINECS: 207-448-8
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB399.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 295-298 °C (dec.) (lit.) |
| Boiling point: | 550.0±33.0 °C(Predicted) |
| alpha | D25 +7.5° (c = 0.37 in pyridine) |
| Density | 1.065±0.06 g/cm3(Predicted) |
| refractive index | 7.8 ° (C=0.9, Pyridine) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| form | Solid |
| pka | 4.61±0.70(Predicted) |
| color | White or off-white |
| optical activity | [α]20/D +7.8°, c = 0.9 in pyridine |
| Merck | 14,1190 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| InChIKey | QGJZLNKBHJESQX-FZFNOLFKSA-N |
| LogP | 7.653 (est) |
Description and Uses
Betulinic acid (472-15-1) is a natural Lupane triterpenoid from white birch tree (Betula pubescens). Induces apoptosis in a variety of cell lines.1 Induces mitochondrial permeability transition pore opening.2 ?Acts as a chemosensitizer for anticancer drug treatment in chemoresistant colon cancer cell lines.3 Cell permeable.
Betulinic acid (BetA) has been used:
- to test its effects as an antiviral agent against Dengue virus (DENV)
- as a sterol regulatory element-binding protein (SREBP) inhibitor to repress the lipid metabolism and proliferation of clear cell renal cell carcinoma (ccRCC) cells
- as a treatment to test its anti-tumor properties for cell viability and apoptotic cell death assays in multiple myeloma models
