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A7021658

Betulinicacid , 10mMinDMSO , 472-15-1

Synonym(s):
3β-Hydroxy-20(29)-lupaene-28-oic acid;Lupatic acid;Mairin

CAS NO.:472-15-1

Empirical Formula: C30H48O3

Molecular Weight: 456.71

MDL number: MFCD00009619

EINECS: 207-448-8

Pack Size Price Stock Quantity
1ml RMB399.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 295-298 °C (dec.) (lit.)
Boiling point: 550.0±33.0 °C(Predicted)
alpha  D25 +7.5° (c = 0.37 in pyridine)
Density  1.065±0.06 g/cm3(Predicted)
refractive index  7.8 ° (C=0.9, Pyridine)
storage temp.  2-8°C
solubility  Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
form  Solid
pka 4.61±0.70(Predicted)
color  White or off-white
optical activity [α]20/D +7.8°, c = 0.9 in pyridine
Merck  14,1190
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey QGJZLNKBHJESQX-FZFNOLFKSA-N
LogP 7.653 (est)

Description and Uses

Betulinic acid (472-15-1) is a natural Lupane triterpenoid from white birch tree (Betula pubescens). Induces apoptosis in a variety of cell lines.1 Induces mitochondrial permeability transition pore opening.2 ?Acts as a chemosensitizer for anticancer drug treatment in chemoresistant colon cancer cell lines.3 Cell permeable.

Betulinic acid (BetA) has been used:

  • to test its effects as an antiviral agent against Dengue virus (DENV)
  • as a sterol regulatory element-binding protein (SREBP) inhibitor to repress the lipid metabolism and proliferation of clear cell renal cell carcinoma (ccRCC) cells
  • as a treatment to test its anti-tumor properties for cell viability and apoptotic cell death assays in multiple myeloma models

Safety

Symbol(GHS) 
GHS06
Signal word  Warning
Hazard statements  H413
Precautionary statements  P501-P273
Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  3
HS Code  29181985

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