PF-06840003 , 98% , 198474-05-4
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB191.20 | In Stock |
|
| 10mg | RMB343.20 | In Stock |
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| 25mg | RMB775.20 | In Stock |
|
| 50mg | RMB1399.20 | In Stock |
|
| 100MG | RMB2519.20 | In Stock |
|
| 250mg | RMB5599.20 | In Stock |
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| others | Enquire |
PRODUCT Properties
| Melting point: | 190-195 °C |
| Boiling point: | 533.2±50.0 °C(Predicted) |
| Density | 1.464±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| form | solid |
| pka | 9.13±0.50(Predicted) |
| color | White |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
PF-06840003 (198474-05-4) is a potent (IC50?= 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1?In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2?PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3
PF-06840003 is a potential clinical candidate as a novel and selective Indoleamine 2,3-dioxygenase inhibitor. Highly selective and orally bioavailable IDO-1 inhibitor.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 |
