1-Methyl-D-tryptophan , 2mMinDMSO , 110117-83-4

CAS NO.：110117-83-4

Empirical Formula: C12H14N2O2

Molecular Weight: 218.25

MDL number: MFCD00274271

PRODUCT Properties

• Melting point: 242-245 °C(lit.)
• alpha: 12.4o (C = 2 IN ACETIC ACID)
• Boiling point: 429.3±35.0 °C(Predicted)
• Density: 1.28
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Soluble in DMSO (greater than 25 mg/ml).
• pka: 2.26±0.10(Predicted)
• form: White to light brown crystalline powder.
• color: White
• optical activity: [α]22/D +12.4°, c = 2 in acetic acid
• Water Solubility: Soluble to 5 mM in water with gentle warming
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
• InChIKey: ZADWXFSZEAPBJS-SNVBAGLBSA-N

Description and Uses

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD⁺ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC₅₀ = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8⁺ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.

1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• WGK Germany: 3