Home Categories Biochemical Engineering 1-Methyl-D-tryptophan
A7687058

1-Methyl-D-tryptophan , 2mMinDMSO , 110117-83-4

CAS NO.:110117-83-4

Empirical Formula: C12H14N2O2

Molecular Weight: 218.25

MDL number: MFCD00274271

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 242-245 °C(lit.)
alpha  12.4o (C = 2 IN ACETIC ACID)
Boiling point: 429.3±35.0 °C(Predicted)
Density  1.28
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Soluble in DMSO (greater than 25 mg/ml).
pka 2.26±0.10(Predicted)
form  White to light brown crystalline powder.
color  White
optical activity [α]22/D +12.4°, c = 2 in acetic acid
Water Solubility  Soluble to 5 mM in water with gentle warming
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey ZADWXFSZEAPBJS-SNVBAGLBSA-N

Description and Uses

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.

1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

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