Dantrolenesodiumsalt , 10mMinDMSO , 14663-23-1
Synonym(s):
1-[(5--(p-Nitro-phenyl)-fur-furyl-idene)-amino]-hydan-toin sodium salt;Dantrolene, Sodium Salt - CAS 14663-23-1 - Calbiochem
CAS NO.：14663-23-1
Empirical Formula: C14H11N4NaO5
Molecular Weight: 338.25
MDL number: MFCD00079130
EINECS: 238-706-8
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | Store at RT |
| solubility | Soluble in DMSO (up to 3 mg/ml) |
| form | Orange solid |
| color | Orange |
| Merck | 14,2816 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month. |
| InChIKey | KSRLIXGNPXAZHD-HAZZGOGXSA-M |
| CAS DataBase Reference | 14663-23-1(CAS DataBase Reference) |
Description and Uses
Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 μg/ml) and MHS pigs (ED50 = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.
Skeletal muscle relaxant;Blocker of Ca2+ release
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Safety Statements | 22-24/25 |
| WGK Germany | 2 |
| RTECS | MU3875000 |
| HS Code | 2942.00.3500 |
