Acemetacin , 10mMinDMSO , 53164-05-9

Synonym(s):
1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester

CAS NO.：53164-05-9

Empirical Formula: C21H18ClNO6

Molecular Weight: 415.82

MDL number: MFCD00151473

EINECS: 258-403-4

PRODUCT Properties

• Melting point: 151.5°C
• Boiling point: 565.5±50.0 °C(Predicted)
• Density: 1.2387 (rough estimate)
• refractive index: 1.6000 (estimate)
• RTECS: NL3521400
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: Practically insoluble in water, soluble in acetone, slightly soluble in anhydrous ethanol.
• form: Solid
• pka: 2.60±0.10(Predicted)
• color: Very fine, pale-yellow crystals from pet eth
• Merck: 14,27
• CAS DataBase Reference: 53164-05-9(CAS DataBase Reference)

Description and Uses

Acemetacin is used in the treatment of pain and restricted mobility resulting from chronic articular rheumatism, degenerative articular disease, gout, and inflammation of muscle, joints, and tendons. Acemetacin causes less gastrointestinal blood loss than indomethacin. Its anti-inflammatory activity results from liberation of the parent compound, indomethacin.

A potent inhibitor of COX-2 found to have anti-tumor activity in the colon

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300+H310+H330
• Precautionary statements: P260-P262-P264-P280-P302+P352+P310-P304+P340+P310
• Hazard Codes: T+
• Risk Statements: 26/27/28
• Safety Statements: 22-25-36/37/39-45-24/25
• RIDADR: UN 2811
• WGK Germany: 3
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 29339900
• Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 55.5, 18.42, 24.2, 30.1 orally; 34.1, 51.1, 38.1, 28.3 i.v. (Jacobi, Dell)