Disopyramide , 10mMinDMSO , 3737-09-5

Synonym(s):
α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide

CAS NO.：3737-09-5

Empirical Formula: C21H29N3O

Molecular Weight: 339.48

MDL number: MFCD00057366

EINECS: 223-110-2

PRODUCT Properties

• Melting point: 94.5-950C
• Boiling point: 475.43°C (rough estimate)
• Density: 1.0779 (rough estimate)
• refractive index: 1.6300 (estimate)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Soluble in DMSO (25 mg/ml) and Ethanol (>35 mg/mL)
• form: solid
• pka: 10.2; also reported as 10.45(at 25℃)
• color: White
• Water Solubility: 6.17mg/L(22.5 ºC)
• Merck: 14,3360
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
• CAS DataBase Reference: 3737-09-5(CAS DataBase Reference)

Description and Uses

Structurally, disopyramide does not belong to any of the known classes of antiarrhythmics; however, being a drug of the class IA sodium channel blockers, it exhibits membranestabilizing action and increases the effective refractory period and duration of an action potential in the atrium and ventricles. It causes a decrease in contractability and excitability of the myocardium, slowing of conductivity, and suppression of sinoatride automatism.

Antiarrhythmic;Na+ channel blocker

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302-H361
• Precautionary statements: P201-P301+P312+P330-P308+P313
• Hazard Codes: Xn,Xi,T,F
• Risk Statements: 22-36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 36-26-45-36/37-16-7
• WGK Germany: 3
• RTECS: UR8432000
• HS Code: 2933.39.4100
• Toxicity: LD50 i.p. in mice: 517 mmol/kg (Ruenitz, Mokler)