Home Categories Chemical Reagents 2-(4-Chlorophenoxy)isobutyricAcid
A6968458

2-(4-Chlorophenoxy)isobutyricAcid , 10mMinDMSO , 882-09-7

Synonym(s):
α-(p-Chlorophenoxy)isobutyric acid;2-(p-Chlorophenoxy)-2-methylpropionic acid;Clofibric acid

CAS NO.:882-09-7

Empirical Formula: C10H11ClO3

Molecular Weight: 214.65

MDL number: MFCD00004192

EINECS: 212-925-9

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 120-122 °C(lit.)
Boiling point: 308.11°C (rough estimate)
Density  1.2413 (rough estimate)
refractive index  1.5220 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform, Methanol
pka 3.18±0.10(Predicted)
form  Crystals or Crystalline Powder
color  Pale yellow to brownish
Merck  14,2378
BRN  1874067
CAS DataBase Reference 882-09-7(CAS DataBase Reference)
NIST Chemistry Reference Clofibric acid(882-09-7)
EPA Substance Registry System Propanoic acid, 2-(4-chlorophenoxy)-2-methyl- (882-09-7)

Description and Uses

Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 μM in a transactivation assay) and the active metabolite of clofibrate . It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 μg/L. Clofibric acid has been found in wastewater effluent.

Antilipemic.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312+P330-P501
Hazard Codes  Xn,Xi
Risk Statements  22-20/21/22
Safety Statements  36-24/25
WGK Germany  3
RTECS  UE9455000
HazardClass  IRRITANT
HS Code  29189900

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