BECHCl , 10mMinDMSO , 222638-67-7
CAS NO.：222638-67-7
Empirical Formula: C5H13BClNO4S
Molecular Weight: 229.48
MDL number: MFCD03453539
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB220.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| color | White to yellow |
Description and Uses
BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 μM from kinetic analyses. It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.
BEC Hydrochloride is Arginase II inhibitor. For the biological study of the inhibition of arginase II, it prevented nitrate tolerance in human umbilical vein endothelial cell and in mouse aorta.
Safety
| Symbol(GHS) |   GHS07,GHS02 |
| Signal word | Warning |
| Hazard statements | H315-H319-H228 |
| Precautionary statements | P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
