Carmustine , 10mMinDMSO , 154-93-8

Synonym(s):
1,3-Bis(2-chloroethyl)-1-nitrosourea;BCNU

CAS NO.：154-93-8

Empirical Formula: C5H9Cl2N3O2

Molecular Weight: 214.05

MDL number: MFCD00057706

EINECS: 205-838-2

PRODUCT Properties

• Melting point: 30 °C (lit.)
• Density: 1.6948 (rough estimate)
• refractive index: 1.6100 (estimate)
• storage temp.: -20°C
• solubility: insoluble in H2O; ≥21.51 mg/mL in DMSO; ≥27.15 mg/mL in EtOH
• form: (Oily liquid to amorphous solid)
• pka: 10.19±0.46(Predicted)
• color: Light-yellow powder
• Water Solubility: <0.1 g/100 mL at 18 ºC
• Merck: 14,1845
• Stability: Temperature Sensitive
• InChIKey: DLGOEMSEDOSKAD-UHFFFAOYSA-N
• CAS DataBase Reference: 154-93-8(CAS DataBase Reference)
• IARC: 2A (Vol. 26, Sup 7) 1987
• EPA Substance Registry System: 1,3-Bis(2-chloroethyl)-1-nitrosourea (154-93-8)

Description and Uses

Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.

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Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300-H350-H360
• Precautionary statements: P201-P280-P301+P330+P331+P310-P308+P313
• Hazard Codes: T+
• Risk Statements: 45-46-60-61-28
• Safety Statements: 53-22-36/37/39-45
• RIDADR: 3249
• WGK Germany: 3
• RTECS: YS2625000
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 29241990
• Hazardous Substances Data: 154-93-8(Hazardous Substances Data)
• Toxicity: LD50 in mice (mg/kg): 19-25 orally, 26 i.p., 24 s.c.; in rats (mg/kg): 30-34 orally (Thompson, Larson)