(+)-Cinchonine , 10mMinDMSO , 118-10-5

Synonym(s):
(+)-Cinchonine;Cinchonine;Cinchonine monohydrochloride dihydrate;NSC 6176

CAS NO.：118-10-5

Empirical Formula: C19H22N2O

Molecular Weight: 294.39

MDL number: MFCD00064372

EINECS: 204-234-6

PRODUCT Properties

• Melting point: 260-263 °C
• alpha: 224 º (c=0.5, alcohol)
• Boiling point: 436.16°C (rough estimate)
• Density: 1.0863 (rough estimate)
• vapor pressure: 0Pa at 25℃
• refractive index: 223 ° (C=0.5, EtOH)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: 0.25g/l
• form: Micro-Crystalline Powder
• pka: 5.85, 9.92(at 25℃)
• color: White to light beige
• PH: 9.0 (0.25g/l, H2O, 20℃)(as aqueous solution)
• optical activity: [α]23/D +228°, c = 0.5 in ethanol
• Water Solubility: Insoluble
• Sensitive: Light Sensitive
• Merck: 14,2287
• BRN: 89689
• Stability: Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
• InChIKey: KMPWYEUPVWOPIM-QHQSXHFQSA-N
• LogP: 2.82 at 25℃
• CAS DataBase Reference: 118-10-5(CAS DataBase Reference)
• NIST Chemistry Reference: Cinchonine(118-10-5)
• EPA Substance Registry System: Cinchonan-9-ol, (9S)- (118-10-5)

Description and Uses

Cinchonine is a cinchona alkaloid generally found in the bark of Cinchona officinalis plants. It is a pseudoenantiomer that is commonly employed in malaria therapy. Cinchonine is also used as an organocatalyst in many asymmetric reactions. It is a stereoisomer and pseudo-enantiomer of cinchonidine. It is structurally similar to quinine, an antimalarial drug.

Stereomeric with Cinchonidine (C441925). Antimalarial.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H317
• Precautionary statements: P261-P264-P270-P280-P301+P312-P302+P352
• Hazard Codes: Xn
• Risk Statements: 20/22-20/21/22
• Safety Statements: 26-36-36/37
• RIDADR: 1544
• WGK Germany: 3
• RTECS: GD3500000
• F: 8-34
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29339900
• Toxicity: LD50 i.p. in rats: 152 mg/kg (Johnson, Poe)