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A6948358

disodiumethydronate , 10mMinWater , 7414-83-7

Synonym(s):
1-Hydroxyethane-1,1-bisphosphonic acid disodium salt;Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate

CAS NO.:7414-83-7

Empirical Formula: C2H9NaO7P2

Molecular Weight: 230.02

MDL number: MFCD00152567

EINECS: 231-025-7

Pack Size Price Stock Quantity
1ml RMB559.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >300 °C
storage temp.  15-25°C
solubility  H2O: 26 mg/mL
form  solid
color  white
Water Solubility  Soluble in water (26 mg/ml).
Merck  14,3863
Stability: Hygroscopic

Description and Uses

Agents in the first generation (e.g., etidronate disodium and tiludronate) that were dosed continuously produced poorly mineralized bone, because there was no interval for appropriate bone mineralization to occur. Subsequent studies that used a cyclic dosing schedule (400 mg/day for 2 weeks, followed by 2.5 months of calcium supplementation only) showed improvement in bone mineralization. Etidronate has been approved for treatment of Paget's disease of the bone but not for treatment of osteoporosis. Tiludronate is approximately 10-fold more potent than etidronate and, when given orally for 6 months (200, 400, or 800 mg/day), increases BMD by 2%. No further bone loss was detected in patients 6 months after cessation of therapy.

Sequestering and chelating agent; scale and corrosion inhibitor.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36/37/39
WGK Germany  1
RTECS  SZ8562240
TSCA  Yes
HS Code  29319090

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