PRODUCT Properties
| Melting point: | 15°C |
| Boiling point: | 155 °C (lit.) |
| Density | 0.99 g/mL at 25 °C (lit.) |
| FEMA | 3272 | 2,5-DIMETHYLPYRAZINE |
| refractive index | n |
| Flash point: | 147 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Liquid |
| pka | 2.21±0.10(Predicted) |
| Specific Gravity | 0.990 |
| color | Clear colorless to pale yellow |
| PH | 7 (H2O) |
| Odor | at 0.10 % in dipropylene glycol. nutty roasted baked potato |
| Odor Type | chocolate |
| Sensitive | Hygroscopic |
| JECFA Number | 766 |
| BRN | 107052 |
| Dielectric constant | 2.4399999999999999 |
| LogP | 0.64 |
| CAS DataBase Reference | 123-32-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyrazine, 2,5-dimethyl-(123-32-0) |
| EPA Substance Registry System | Pyrazine, 2,5-dimethyl- (123-32-0) |
Description and Uses
2,5-Dimethylpyrazine is used as a reagent in the synthesis of bone-targeted proteasome inhibitors for multiple myeloma (MM). 2,5-Dimethylpyrazine is also used in the preparation of 3-Methyl-2,5-bis-(2-hydroxyethyl)pyrazine (M295340); a degredation product of Clavulanic Acid (C563750) which is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38-R22 |
| Safety Statements | 26-36 |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | 3 |
| RTECS | UQ2800000 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29339990 |
