Home Categories 9-Phenylacridine
A6929412

9-Phenylacridine , >98.0% , 602-56-2

CAS NO.:602-56-2

Empirical Formula: C19H13N

Molecular Weight: 255.31

MDL number: MFCD00092562

EINECS: 210-020-3

Pack Size Price Stock Quantity
5G RMB150.40 In Stock
10G RMB229.60 In Stock
25G RMB465.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 184°C
Boiling point: 388.54°C (rough estimate)
Density  0.9418 (rough estimate)
refractive index  1.6500 (estimate)
storage temp.  Sealed in dry,Room Temperature
form  powder to crystal
pka 5.45±0.10(Predicted)
color  Light yellow to Amber to Dark green
InChI InChI=1S/C19H13N/c1-2-8-14(9-3-1)19-15-10-4-6-12-17(15)20-18-13-7-5-11-16(18)19/h1-13H
InChIKey MTRFEWTWIPAXLG-UHFFFAOYSA-N
SMILES C1C2C(=NC3C(C=2C2=CC=CC=C2)=CC=CC=3)C=CC=1
CAS DataBase Reference 602-56-2(CAS DataBase Reference)
NIST Chemistry Reference Acridine, 9-phenyl-(602-56-2)
EPA Substance Registry System Acridine, 9-phenyl- (602-56-2)

Description and Uses

9-Phenylacridine has antitumour activity. It can be used as a photosensitiser and can sensitise UVA-induced DNA damage in vitro and in cells. It also enhances cell killing by UVA. In addition. It is also used in photochemical research and as a raw material for organic synthesis.

Research has found that 9-phenylacridine (ACPH) exhibited anticancer activity in cell lines and in vivo animal models. Bioinformatics studies have indicated that it could have topoisomerase I inhibitory activity. It could also act as a PARP 1 inhibitor and was very effective in combination with cisplatin in cell line-based assays. ACPH also satisfied all criteria for a candidate drug from the Lipinski rule and showed good cell uptake. ACPH alone was effective in the A375 melanoma cell line. ACPH could be used as a promising new photosensitizer[1-2]. 9-Phenylacridine is the parent base of chrysaniline or 3,6-diamino-9- phenylacridine, the chief constituent of the dyestuff phosphine. It is commonly used in the electronics industry as a free radical photoinitiator, significantly improving photo speed.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  22-24/25
HS Code  2933.99.8210

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