Perphenazine , >97.0% , 58-39-9

Synonym(s):
4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol;Perphenazine

CAS NO.：58-39-9

Empirical Formula: C21H26ClN3OS

Molecular Weight: 403.97

MDL number: MFCD00056798

EINECS: 200-381-5

PRODUCT Properties

• Melting point: 95-98?C
• Boiling point: bp0.15 214-218°; bp1 278-281°
• Density: 1.253
• refractive index: 1.6100 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, freely soluble in methylene chloride, soluble in ethanol (96 per cent). It dissolves in dilute solutions of hydrochloric acid.
• form: Solid
• pka: pKa 7.8(H2O,t =24±1) (Uncertain)
• color: White
• Water Solubility: 28.28mg/L(24 ºC)
• Merck: 14,7183
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Description and Uses

Perphenazine (58-39-9) is a clinically useful typical antipsychotic drug. The therapeutic mode of action is not well understood but it binds to a wide variety of receptors including serotonin, histamine, dopamine, and α-adrenergic.1 Perphenazine is an inhibitor of acid sphingomyelinase(ASM)2 and positively affected xenografted tumor growth via perturbation of intracellular cholesterol transport through ASM3. It has also been shown to be an inhibitor of glutamate dehydrogenase.4

immune suppressant, antifungal

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H317
• Precautionary statements: P261-P264-P270-P280-P301+P312-P302+P352
• Hazard Codes: Xn
• Risk Statements: 22-43
• Safety Statements: 28-36/37/39-45
• RIDADR: UN 2811 6.1 / PGII
• WGK Germany: 3
• RTECS: TL7175000
• HS Code: 29349990
• Toxicity: LD50 oral in rat: 318mg/kg