1-Palmitoyl-sn-glycero-3-phosphocholine , >99% , 17364-16-8
Synonym(s):
PC(16:0/0:0);L -α-Palmitoyl-lysophosphatidylcholine;L -γ-Palmitoyl-α-lysolecithin;1-Hexadecanoyl-sn-glycero-3-phosphocholine;1-hexadecanoyl-sn-glycero-3-phosphocholine; PC(16:0/0:0)
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB370.40 | In Stock |
|
| 100MG | RMB658.40 | In Stock |
|
| 500MG | RMB1103.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 253 °C |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| color | White to Off-White |
| BRN | 5385682 |
Description and Uses
1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine. It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and phosphorylation of ERK1/2 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 125 μM. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages when used at concentrations of 0.3 and 1.0 μM. It increases TGF-β1 production and enhances Foxp3 protein levels in Treg cells in isolated human peripheral blood when used at a concentration of 10 μM. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis when administered at a dose of 10 mg/kg.
16:0 Lyso PC has been used to reveal the central role of the adipocyte inflammasome in homocysteine-induced insulin resistance. It has also been used for lipid extraction and mass spectrometry analysis.
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H302-H315-H319-H331-H336-H351-H361d-H372-H412 |
| Precautionary statements | P201-P273-P301+P312+P330-P302+P352-P304+P340+P311-P308+P313 |
| WGK Germany | 3 |
| F | 10-21 |
| HS Code | 2923.20.2000 |
