Pancuronium dibromide , ≥99% , 15500-66-0
Synonym(s):
;1,1′-[(2β,3α,5α,16β,17β)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide;Pancuronium Dibromide - CAS 15500-66-0 - Calbiochem
CAS NO.：15500-66-0
Empirical Formula: C35H60Br2N2O4
Molecular Weight: 732.67
MDL number: MFCD00079223
EINECS: 239-532-5
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB408.00 | In Stock |
|
| 100MG | RMB1292.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 215° |
| Boiling point: | ~100°C |
| Density | ~1, mp: 0°C |
| storage temp. | 2-8°C |
| solubility | Very soluble or freely soluble in water, very soluble in methylene chloride, freely soluble in ethanol (96 per cent). |
| form | Off-white solid |
| color | Clear, colorless solution |
| Odor | Odorless |
| Merck | 13,7077 |
| BRN | 4226892 |
| InChIKey | NPIJXCQZLFKBMV-LQDGISGANA-L |
| CAS DataBase Reference | 15500-66-0(CAS DataBase Reference) |
Description and Uses
Pancuronium bromide, a bisquaternary amine and the first steroid N MBA used clinically, was developed by Savege and Hewitt and marketed in 1964. The intubating dose is 0.1mgkg–1, which takes 3-4min to reach its maximum effect. The clinical duration of action of the drug is long, especially in the presence of potent inhalational agents or renal dysfunction, as 60% of a dose of the drug is excreted unchanged through the kidneys. I t is also deacetylated in the liver; some of the metabolites have neuromuscular blocking properties.
Pancuronium does not stimulate histamine release; however, it has direct vagolytic and sympathomimetic effects which may cause tachycardia and hypertension. It slightly inhibits plasma cholinesterase and therefore potentiates any drug metabolised by this enzyme, such as suxamethonium and mivacurium.
Pancuronium is a steroid compound that does not possess hormonal activity. It is used in anesthesiology as a myorelaxant, causing prolonged muscle relaxation during surgical interventions of the thoracic and abdominal cavities, in proctology, ophthalmology, orthopedic practice, and in heart surgeries. A synonym of this drug is pavulon.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P310 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TN4930000 |
| F | 10-21-33 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2933399090 |
| Hazardous Substances Data | 15500-66-0(Hazardous Substances Data) |
| Toxicity | LD50 in mice (mg/kg): 0.047 i.v.; 0.152 i.p.; 0.167 s.c.; 21.9 orally; in rats, rabbits: 0.153, 0.016 i.v. (Buckett, 1968) |
