Pifithrin-α (PFTα) , ≥97% , 63208-82-2

Synonym(s):
2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1- p-tolylethanone, HBr;2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide;PFT-α;Pifithrin-α - CAS 63208-82-2 - Calbiochem

CAS NO.：63208-82-2

Empirical Formula: C16H19BrN2OS

Molecular Weight: 367.3

MDL number: MFCD00417851

PRODUCT Properties

• Melting point: 192.1-192.5 °C(lit.)
• storage temp.: -20°C
• solubility: DMSO: 20 mg/mL
• form: powder
• pka: 9.11(at 25℃)
• color: off-white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Description and Uses

Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 μM and in human umbilical vein endothelial cells at 30 μM. Pifithrin-α can also protect cells from DNA damage-induced apoptosis by a p53-independent mechanism that might involve cyclin D1.

Pifithrin-α has been used:

• to study the effect of specific p53 inhibitor on p53-upregulated modulator of apoptosis (PUMA) expression after transient global cerebral ischemia (tGCI)
• as p53 inhibitor to treat PA1 cells
• as a tumor protein p53 (TRP53) inhibitor, to treat mouse lung epithelial-12 (MLE-12) cells

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• WGK Germany: 3
• HS Code: 2934.20.8000