RITA (NSC 652287) , ≥98% , 213261-59-7

Synonym(s):
NSC 652287, 2,5- bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X;p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem

CAS NO.：213261-59-7

Empirical Formula: C14H12O3S2

Molecular Weight: 292.37

MDL number: MFCD03235294

EINECS: 200-256-5

PRODUCT Properties

• Melting point: 160 °C
• Boiling point: 464.9±40.0 °C(Predicted)
• Density: 1.396±0.06 g/cm3(Predicted)
• storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• solubility: Soluble in DMSO (up to 20 mg/ml)
• pka: 13.43±0.10(Predicted)
• form: Crystalline solid
• color: Yellow
• Sensitive: Light Sensitive
• Stability: Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Description and Uses

RITA (reactivation of p53 and induction of tumor cell apoptosis, 213261-59-7) binds to p53 (Kd = 1.5 nM), changing its conformation, preventing it from binding to HDM2 and preventing its proteasomal degradation.1 It also weakly (computed Kd = 22 μM) binds HDM2 in the cleft that contacts the p53 transactivation domain.2 Its restoration of mutant p53 function depends on eIF2α phosphorylation, and it induces apoptosis via p53-dependent and -independent (JNK/SAPK/p38; protein translation) pathways.3-5 Induces senescence in head and neck cancer cells.6

NSC 652287, a DNA damaging agent. It induces p53 tumor suppressor protein.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H227
• Precautionary statements: P501-P270-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P403+P235
• HS Code: 29321900