Proflavine Hemisulfate , ≥97% , 1811-28-5

Synonym(s):
3,6-Diaminoacridine hemisulfate salt

CAS NO.：1811-28-5

Empirical Formula: C26H24N6O4S

Molecular Weight: 516.57

MDL number: MFCD00013150

EINECS: 217-320-3

PRODUCT Properties

• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: DMSO (Slightly, Heated), Water (Slightly, Heated)
• form: powder
• color: Orange to Amber to Dark red
• PH: pH (1g/l, 25℃) : 4.0～8.0
• Water Solubility: H2O: 10mg/mL
• BRN: 3921806
• Stability: Hygroscopic
• EPA Substance Registry System: 3,6-Acridinediamine, sulfate (2:1) (1811-28-5)

Description and Uses

Proflavine Hemisulfate, the hemisulfate form of proflavin, is an acridine-derived fluorescent contrast agent and disinfectant used for cell imaging and antiseptic purposes. Following topical application, proflavin diffuses into cells and intercalates into DNA, leading to its accumulation in and staining of the nucleus. This allows visualization of the nucleus during fluorescence imaging. Such capability enables nuclear morphometry and facilitates the identification of cancer cells. Additionally, proflavin sulfate exerts antimicrobial effects through binding to bacterial DNA, which disrupts DNA synthesis and inhibits bacterial cell growth.

An Acridine derivative with limited antifungal activity

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: AR9065100
• F: 3-8-10-23
• HS Code: 2918.19.9000
• Toxicity: mouse,LD50,subcutaneous,200mg/kg (200mg/kg),Quarterly Journal of Pharmacy & Pharmacology. Vol. 10, Pg. 649, 1937.