Primidone , ≥98%(HPLC) , 125-33-7

Synonym(s):
2-Desoxyphenobarbital;5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione;Primidone

CAS NO.：125-33-7

Empirical Formula: C12H14N2O2

Molecular Weight: 218.25

MDL number: MFCD00038662

EINECS: 204-737-0

PRODUCT Properties

• Melting point: 281-282°C
• Boiling point: 358.94°C (rough estimate)
• Density: 1.1402 (rough estimate)
• refractive index: 1.6660 (estimate)
• Flash point: 9℃
• storage temp.: Sealed in dry,Room Temperature
• solubility: Very slightly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in alkaline solutions.
• form: Solid
• pka: 12.26±0.40(Predicted)
• color: White to Off-White
• Water Solubility: <0.1 g/100 mL at 19 ºC
• Merck: 14,7746
• BCS Class: 2
• InChIKey: DQMZLTXERSFNPB-UHFFFAOYSA-N
• CAS DataBase Reference: 125-33-7(CAS DataBase Reference)
• IARC: 2B (Vol. 108) 2016
• NIST Chemistry Reference: Primidone(125-33-7)
• EPA Substance Registry System: Primidone (125-33-7)

Description and Uses

Primidone is chemically and structurally similar to phenobarbital with the exception that the carbonyl group on C2 is replaced by a methylene group. This modification leads to the production of a drug with strong anticonvulsant properties without expressed soporific effects.

Primidone is an Anticonvulsant.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302-H351-H361d
• Precautionary statements: P201-P202-P264-P270-P301+P312-P308+P313
• Hazard Codes: Xn,T,F
• Risk Statements: 22-40-39/23/24/25-23/24/25-11
• Safety Statements: 22-36-45-36/37-16-7
• RIDADR: 3249
• WGK Germany: 3
• RTECS: UV9100000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29335990
• Hazardous Substances Data: 125-33-7(Hazardous Substances Data)
• Toxicity: child,TDLo,oral,625mg/kg (625mg/kg),BEHAVIORAL: SLEEPBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: GENERAL ANESTHETIC,British Medical Journal. Vol. 1, Pg. 90, 1957.