A6793912
PHA-767491 , ≥98% , 845714-00-3
Synonym(s):
1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride;2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride;PHA-00767491 hydrochloride
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB239.20 | In Stock |
|
| 25MG | RMB799.20 | In Stock |
|
| 100MG | RMB2639.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Density | 1.287 |
| storage temp. | Desiccate at RT |
| solubility | insoluble in H2O; insoluble in EtOH; ≥10.65 mg/mL in DMSO |
| form | solid |
| Stability: | Hygroscopic |
Description and Uses
PHA 767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2).
