Pazopanib , ≥99% , 444731-52-6
Synonym(s):
5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide;GW 786034;GW786034
CAS NO.：444731-52-6
Empirical Formula: C21H23N7O2S
Molecular Weight: 437.52
MDL number: MFCD11616589
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB383.20 | In Stock |
|
| 100MG | RMB1039.20 | In Stock |
|
| 500MG | RMB4159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 285-289°C (dec.) |
| Boiling point: | 728.8±70.0 °C(Predicted) |
| Density | 1.40 |
| Flash point: | 359℃ |
| storage temp. | Refrigerator |
| solubility | Aqueous Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated) |
| pka | 10.19±0.60(Predicted) |
| form | Yellow powder. |
| color | White to Beige |
Description and Uses
Pazopanib is a multi-kinase inhibitor that inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC50s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay). It also inhibits PDGFRα, PDGFRβ, and c-Kit (IC50s = 71, 84, and 74 nM, respectively, in a cell-free enzyme assay) as well as additional receptor tyrosine kinases. Pazopanib inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells cocultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs. It also inhibits proliferation of multiple myeloma cells cocultured with HUVECs. Pazopanib (30 and 100 mg/kg) reduces tumor growth, induces apoptosis, decreases angiogenesis, and increases survival in a multiple myeloma mouse xenograft model. Formulations containing pazopanib have been used in the treatment of cancer.
Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.
Safety
| Symbol(GHS) |   GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H360FD-H373-H411 |
| Precautionary statements | P202-P260-P273-P280-P308+P313-P391 |
| Risk Statements | 43-62/63 |
| Safety Statements | 36/37/39-28B |
| HS Code | 29350090 |
