3-Methyl-6-nitroindazole , 98% , 6494-19-5

CAS NO.：6494-19-5

Empirical Formula: C8H7N3O2

Molecular Weight: 177.16

MDL number: MFCD07082704

EINECS: 613-731-0

PRODUCT Properties

• Melting point: 187-188°C
• Boiling point: 384.9±22.0 °C(Predicted)
• Density: 1.437
• storage temp.: Sealed in dry,Room Temperature
• solubility: Chloroform (Slightly), Methanol (Slightly)
• pka: 11.47±0.40(Predicted)
• form: Solid
• color: Beige to Dark Yellow
• InChI: InChI=1S/C8H7N3O2/c1-5-7-3-2-6(11(12)13)4-8(7)10-9-5/h2-4H,1H3,(H,9,10)
• InChIKey: FUNWSYKLFDLUIZ-UHFFFAOYSA-N
• SMILES: N1C2=C(C=CC([N+]([O-])=O)=C2)C(C)=N1

Description and Uses

3-Methyl-6-nitroindazole is an important organic reagent or pharmaceutical intermediate compound used in the preparation of key intermediates of pazopanib. In experimental studies, it is mostly used for solubility determination, correlation and molecular interaction analysis studies in different pure and mixed solvents. The results showed that in the temperature range of (278.15 ~ 328.15)K, the molar fraction solubility of 3-Methyl-6-nitroindazole increased with increasing temperature in both pure and mixed solvent systems, and was maximum in pure N, N-dimethylformamide and minimum in water.

3-Methyl-6-nitroindazole a reactant used in the preparation of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312+H332-H315-H319
• Precautionary statements: P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312
• Risk Statements: 20/21/22
• Safety Statements: 24/25-36/37
• HS Code: 29339900