Home Categories API D-Penicillamine
A6737812

D-Penicillamine , >98.0%(T) , 52-67-5

Synonym(s):
D-(−)-2-Amino-3-mercapto-3-methylbutanoic acid;D-Penicillamine;3,3-Dimethyl-D-cysteine;3-Mercapto-D-valine

CAS NO.:52-67-5

Empirical Formula: C5H11NO2S

Molecular Weight: 149.21

MDL number: MFCD00064302

EINECS: 200-148-8

Pack Size Price Stock Quantity
5G RMB151.20 In Stock
25G RMB577.60 In Stock
100G RMB1479.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 210 °C (dec.)(lit.)
Boiling point: 251.8±35.0 °C(Predicted)
alpha  -65 º (c=5, 1M NaOH, on dry)
Density  1.113 (estimate)
refractive index  -63 ° (C=1, 1mol/L NaOH)
storage temp.  2-8°C
solubility  H2O: soluble100mg/mL
pka pKa 7.83±0.01(H2O,t =37±0.05,I=0.15)(Approximate)
form  Powder
color  White to almost white
optical activity -6325 (pyridine), L-form: +6325 (1 mol dm-3 NaOH)
Water Solubility  11.1 g/100 mL (20 ºC)
Merck  14,7088
BRN  1722375
BCS Class 3
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey VVNCNSJFMMFHPL-VKHMYHEASA-N

Description and Uses

Penicillamine is an orally bioavailable copper chelator and penicillin degradation product. It increases urinary and fecal copper excretion and decreases liver copper concentration in a rat model of copper overload when administered at 0.67 mmol/kg per day, but does not affect kidney, spleen, or brain copper levels. Penicillamine (100 mg/kg per day) dissolves copper-rich granules in hepatic lysosomes of Long-Evans cinnamon (LEC) rats, which spontaneously develop hepatic injury and acute hepatitis and have a mutation homologous to that of the human Wilson disease gene. Penicillamine has anticonvulsant and proconvulsant effects in mice when administered at 0.5 and 250 mg/kg, respectively, which are blocked by the nitric oxide synthase (NOS) inhibitors L-NAME and 7-nitroindazole . Formulations containing penicillamine have been used to treat Wilson disease, cystinuria, and active rheumatoid arthritis.

chelating agent (Cu), antirheumatic

Safety

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361d
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
Hazard Codes  Xi,T,Xn
Risk Statements  36/37/38-40-20/21/22
Safety Statements  26-36-24/25-22
WGK Germany  2
RTECS  YV9425000
Hazard Note  Toxic
HS Code  29309016
Toxicity LD50 in rats (mg/kg): >10000 orally, >660 i.p. (Jaffe)

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