PRODUCT Properties
| Melting point: | 119-121 °C(lit.) |
| Boiling point: | 288.88°C (rough estimate) |
| Density | 1.1436 (rough estimate) |
| vapor pressure | 0.002Pa at 25℃ |
| refractive index | 1.5600 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear |
| form | White to off-white solid. |
| pka | 9.50±0.30(Predicted) |
| color | White to Light yellow to Light orange |
| Water Solubility | SOLUBLE IN HOT WATER |
| Merck | 14,7309 |
| BRN | 131856 |
| Stability: | Stable, but light sensitive. Incompatible with strong acids, strong oxidizing agents, strong bases. |
| LogP | 0.119 at 25℃ |
| CAS DataBase Reference | 92-43-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Phenyl-3-pyrazolidinone(92-43-3) |
| EPA Substance Registry System | 3-Pyrazolidinone, 1-phenyl- (92-43-3) |
Description and Uses
Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H302-H411 |
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 |
| Hazard Codes | Xn,N |
| Risk Statements | 22-51/53 |
| Safety Statements | 61 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | UQ8750000 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29331990 |
| Toxicity | LD50 orl-rat: 200 mg/kg KODAK* -,-,71 |
