Puromycin aminonucleoside , 98% , 58-60-6
Synonym(s):
3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
CAS NO.：58-60-6
Empirical Formula: C12H18N6O3
Molecular Weight: 294.31
MDL number: MFCD00063462
EINECS: 200-388-3
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB431.20 | In Stock |
|
| 25MG | RMB1332.80 | In Stock |
|
| 100MG | RMB4799.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 235℃ (Decomposition) |
| Boiling point: | 436.08°C (rough estimate) |
| Density | 1.2131 (rough estimate) |
| refractive index | 1.7000 (estimate) |
| Flash point: | >110°(230°F) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | H2O: 50 mg/mL, clear, slightly yellow |
| form | liquid |
| pka | 13.26±0.70(Predicted) |
| color | White |
| Water Solubility | Soluble in water at 50mg/ml. May require heating |
| BRN | 93902 |
| Stability: | Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. |
| InChIKey | RYSMHWILUNYBFW-GRIPGOBMSA-N |
Description and Uses
Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis.1?It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo.
Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells.
