Home Categories Biochemical Engineering Otilonium Bromide
A6544812

Otilonium Bromide , ≥98% , 26095-59-0

Synonym(s):
N,N-Diethyl-N-methyl-2-[(4-{[2-(octyloxy)benzoyl]amino}benzoyl)oxy]ethanaminium bromide;N,N-Diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-ethanaminium bromide;Octylonium bromide

CAS NO.:26095-59-0

Empirical Formula: C29H43BrN2O4

Molecular Weight: 563.57

MDL number: MFCD00211142

EINECS: 247-457-4

Pack Size Price Stock Quantity
5G RMB202.40 In Stock
25G RMB640.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 130-133°C
storage temp.  -20°C
solubility  DMSO (Slightly), Methanol (Slightly)
form  powder
color  white to beige
CAS DataBase Reference 26095-59-0(CAS DataBase Reference)

Description and Uses

Otilonium is an inhibitor of L-type (IC50 = 2.3 μM) and T-type calcium channels (IC50s = 0.8, 1.1, and 0.4 μM for Cav3.1, Cav3.2, and Cav3.3, respectively). It is also an antagonist of muscarinic acetylcholine receptors (mAChRs; IC50s = 0.054, 0.4, 0.222, and 0.156 μM for M1, M2, M4, and M5 muscarinic receptors, respectively) and the platelet activating factor (PAF) receptor (IC50 = 0.0552 μM). Otilonium inhibits the inward calcium current in isolated rat colonic smooth muscle cells (EC50 = 885 nM), an effect that can be blocked by the L-type calcium channel inhibitor nifedipine . It inhibits contractions induced by the muscarinic acetylcholine receptor (mAChR) agonist methacholine in isolated circular muscle of the guinea pig proximal colon (IC50 = 3.7 μM). Otilonium (4 mg/kg) decreases fecal excretion and wet dog shakes and increases the tail withdrawal latency in the tail-flick test in a rat model of opioid withdrawal syndrome induced by morphine and naloxone.

Otilonium bromide is an antimuscarinic

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338
Toxicity LD50 in mice (mg/kg) 87.0 i.p.

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