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A6534112

Oxolinic acid , Analysis standard , 14698-29-4

Synonym(s):
5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid

CAS NO.:14698-29-4

Empirical Formula: C13H11NO5

Molecular Weight: 261.23

MDL number: MFCD00056775

EINECS: 238-750-8

Pack Size Price Stock Quantity
250MG RMB636.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 314-316°C (dec.)
Boiling point: 473℃
Density  1.3038 (rough estimate)
refractive index  1.5500 (estimate)
Flash point: >110°(230°F)
storage temp.  2-8°C
solubility  Soluble in 0.5N NaOH with warming
pka 5.94±0.20(Predicted)
form  Crystalline Powder
color  White
Water Solubility  3.214mg/L(temperature not stated)
Sensitive  Light Sensitive
Merck  13,7014
BRN  620635
Stability: Stable. Combustible.
InChIKey KYGZCKSPAKDVKC-UHFFFAOYSA-N
CAS DataBase Reference 14698-29-4(CAS DataBase Reference)
EPA Substance Registry System Oxolinic acid (14698-29-4)

Description and Uses

Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-stranded DNA. Oxolinic acid is a quinolone antibiotic that inhibits bacterial DNA gyrase, but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 μg/ml. Oxolinic acid also blocks neuronal uptake of dopamine in mammals (IC50 = 4.3 μM), leading to an increase in locomotor activity.

Quinolone antibacterial.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-24/25-60-36
WGK Germany  3
RTECS  JI5075000
10
HS Code  29349990
Hazardous Substances Data 14698-29-4(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): >6000, >2000 orally (Turner)

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