Osthole , 99% , 484-12-8

Synonym(s):
7-Methoxy-8-(3-methyl-2-butenyl)coumarin;7-Methoxy-8-isopentenylcoumarin;Osthol

CAS NO.：484-12-8

Empirical Formula: C15H16O3

Molecular Weight: 244.29

MDL number: MFCD00076049

EINECS: 1532714-185-1

PRODUCT Properties

• Melting point: 83-84°C
• Boiling point: 347.2°C (rough estimate)
• Density: 1.1263 (rough estimate)
• refractive index: 1.5570 (estimate)
• storage temp.: Sealed in dry,2-8°C
• solubility: methanol: soluble10mg/mL, clear, colorless
• form: powder
• color: white
• Odor: at 100.00 %. dry musty herbal
• Odor Type: dry
• Water Solubility: 12mg/L(25 ºC)
• λmax: 322nm(MeOH)(lit.)
• Merck: 14,6895
• InChIKey: MBRLOUHOWLUMFF-UHFFFAOYSA-N
• LogP: 3.686 (est)

Description and Uses

Cnidium is a Chinese medicine which is used widely by traditional medicine doctors. Cnidium has been recorded in almost all of the pharmaceutical monographs , including Shen Nong’s Classic Materia Medica, New Materia Medica, Compendium of Materia Medica, etc. Osthole is a major bioactivity compound of the Cnidium, which has the effect of dampness dispelling, insecticidal antipruritic,and aphrodisiac and is used for the treatment for pruritus and eczema, lumbago,kidney impotence, and infertility .
Osthole is derived from Umbelliferae and Rutaceae plants. Osthole is also distributed in Asteraceae and Leguminosae plants. Osthole is present in 14 genera of Umbelliferae plants: danggui (Angelica L.), gudanggui (Archangelica Hoffm.), mianguoqin (Cachrys L.), shechuang (Cnidium Cusson), awei (Ferula L.), duhuo (Heracleum L.), yanfeng (Libanotis Hill), ouqin (Petroselinum Hill), qianhu (Peucedanum L.), huiqin (Pimpinella L.), liangshechuang (Selinum L.). Shuanchiqin (Prangos Lindl), xifengqin (Seseli L.), oufangfeng (Pastinaca L.). Osthole is present in 17 genera of Rutaceae plants: ganju (Citrus L.), huangpi (Clausena Burm. F.), xiangju (Feronia Correa), jupanmu (Flindersia R. Br.), niyunxiang (Haplophyllum A. Juss.), mizhuyu (Melicope J. R. and G. Forst.), xiaoyunmu (Micromelum Bl.), jiulixiang (Murraya Koenig ex L.), zhi (Poncirus Raf.), yinyu (Skimmia Thunb.), Limonia, Myrtopsis, Pentaceras, Phebalium, Pilocarpus, Thamnosma, Ticorea) .

Osthole inhibits the PI3K/Akt pathway thus inhibiting insulin-like growth factor-1 (IGF-1)-induced epithelial-to-mesenchymal transition (EMT) in brain cancer. Osthole may be used in the treatment of Glioblastoma multiforme (GBM).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319
• Precautionary statements: P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
• WGK Germany: 3
• RTECS: GN7700000
• HS Code: 29322090