Home Categories N6-Methyladenosine
A6490112

N6-Methyladenosine , 98% , 1867-73-8

CAS NO.:1867-73-8

Empirical Formula: C11H15N5O4

Molecular Weight: 281.27

MDL number: MFCD00005739

EINECS: 200-001-2

Pack Size Price Stock Quantity
250MG RMB248.00 In Stock
1G RMB888.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 172 °C
Boiling point: 649.1±65.0 °C(Predicted)
Density  1.85±0.1 g/cm3(Predicted)
storage temp.  Keep in dark place,Sealed in dry,2-8°C
solubility  DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form  Powder
pka 13.12±0.70(Predicted)
color  White to off-white
PH 4.0
λmax 262 (pH 1);266 (pH 7)
Stability: Hygroscopic

Description and Uses

N6-Methyladenosine is an adenosine analog. It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs. It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas. N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.

N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning

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