Nonactin from Streptomyces griseus var griseus , ≥96% , 6833-84-7
Synonym(s):
Ammonium ionophore;Nonactin
CAS NO.：6833-84-7
Empirical Formula: C40H64O12
Molecular Weight: 736.93
MDL number: MFCD00043039
EINECS: 229-911-3
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB443.20 | In Stock |
|
| 25MG | RMB1599.20 | In Stock |
|
| 100MG | RMB4799.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 147-148° |
| Boiling point: | 890.6±65.0 °C(Predicted) |
| Density | 1.11-1.15 g/cm3 |
| storage temp. | 2-8°C |
| solubility | chloroform: soluble10mg/mL |
| form | White to off-white crystalline solid. |
| color | white to faint yellow |
| Sensitive | Moisture Sensitive |
| Merck | 13,6709 |
| BRN | 76434 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
Description and Uses
Nonactin (6833-84-7) is a monovalent cation ionophore with high selectivity for NH4+ and K+ .1 Upregulates levels of mitochondrial stress proteins HSP58 and GRP75.2 Nonactin abolishes mitochondrial membrane potential.3
Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | RH1685000 |
| F | 10-21 |
| HS Code | 29321900 |
| Toxicity | LD50 intravenous in mouse: 246mg/kg |
