Nevirapine , ≥98%(HPLC) , 129618-40-2

Synonym(s):
11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one;Nevirapine

CAS NO.：129618-40-2

Empirical Formula: C15H14N4O

Molecular Weight: 266.3

MDL number: MFCD00866928

EINECS: 603-345-0

PRODUCT Properties

• Melting point: 247°C
• Boiling point: 409.5°C (rough estimate)
• Density: 1.1300 (rough estimate)
• refractive index: 1.6200 (estimate)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: DMSO: ≥22mg/mL
• form: powder
• pka: 2.8(at 25℃)
• color: white to tan
• Water Solubility: 0.1g/L(temperature not stated)
• Merck: 14,6490
• BCS Class: 2
• CAS DataBase Reference: 129618-40-2(CAS DataBase Reference)
• EPA Substance Registry System: 6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl- (129618-40-2)

Description and Uses

Nevirapine and its analogues exhibit antiretroviral effect against azothymidine-resistant HIV strains. Nevirapine in combination with ZDV and ddI produced approximately 18% higher CD4 cell counts and a decrease in viral load compared with patients who took ZDV and ddI. Nevirapine is recommended with nucleosides for patients infected with HIV-1 who have experienced clinical or immunologic deterioration. The significant side effects of nevirapine are liver dysfunction and skin rashes.

amyloidosis therapy

Safety

• Symbol(GHS): GHS02,GHS06,GHS08
• Signal word: Danger
• Hazard statements: H225-H301+H311+H331-H370
• Precautionary statements: P210-P260-P280-P301+P310-P311
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 2
• RTECS: JM5562500
• HS Code: 29339900
• Hazardous Substances Data: 129618-40-2(Hazardous Substances Data)