Home Categories Analytical Chemistry 1-Nitrosopyrrolidine
A6182912

1-Nitrosopyrrolidine , Analysis standard , 930-55-2

Synonym(s):
N-Nitrosopyrrolidine;NPYR

CAS NO.:930-55-2

Empirical Formula: C4H8N2O

Molecular Weight: 100.12

MDL number: MFCD00003166

EINECS: 213-218-8

Pack Size Price Stock Quantity
100MG RMB876.80 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Boiling point: 214 °C(lit.)
Density  1.085 g/mL at 25 °C(lit.)
refractive index  n20/D 1.489(lit.)
Flash point: 182 °F
storage temp.  Sealed in dry,2-8°C
solubility  Chloroform (Sparingly), Ethyl Acetate, Methanol (Slightly)
form  Oil
pka -3.14±0.20(Predicted)
color  Pale Yellow to Yellow
CAS DataBase Reference 930-55-2(CAS DataBase Reference)
IARC 2B (Vol. 17, Sup 7) 1987
EPA Substance Registry System N-Nitrosopyrrolidine (930-55-2)

Description and Uses

N-Nitrosopyrrolidine (NPYR) is a nitrosamine compound that is used primarily as a research chemical and is not produced commercially. There is the possibility of generating NPYR after frying in dry-cured bacon. The major amine precursors to NPYR in cooked bacon are free proline in the adipose tissue and to a lesser extent, collagenous connective tissues. When proline peptides were heated with nitrite at pH 3.4, small amounts of NPYR were formed from all tested peptides. There are several potential sources of exposure of man to this group of potent carcinogens. Certain foods were thought to be derived from the interaction of nitrite with secondary amines in the food, either spontaneously or by the agency of bacteria. Recently the possibility that nitrosamines may be formed from secondary amines and nitrite in the gastrointestinal tract has been explored. The acid conditions that prevail in the human stomach favor the nitrosation of dimethylamine. In addition, at neutral pH, many secondary amines can be nitrosated by nitrite or nitrate in the presence of intestinal bacteria, or the cecal contents of the rat, and soluble enzymes which catalyze the N-nitrosation of several secondary amines have been extracted from two microorganisms. The rate of nitrosamine formation depends greatly on the basicity of the amine; the less basic amines such as diphenylamine and pyrrolidine are nitrosated far more readily than the strongly basic dimethylamine and diethylamine.

One of the N-nitroso compounds (NOCs) implicated in human colon carcinogenesis, but the toxicological mechanisms involved have not been elucidated.

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H351
Precautionary statements  P281
Hazard Codes  Xn
Risk Statements  40
RIDADR  2810
WGK Germany  3
RTECS  UY1575000
HazardClass  6.1(b)
PackingGroup  III
Hazardous Substances Data 930-55-2(Hazardous Substances Data)
Toxicity LD50 orally in rats: 900 mg/kg (Druckrey)

RELATED PRODUCTS